Andy Roddick was born in Omaha, Nebraska, on 30 August 1982, the youngest of three sons. The family lived in Austin, Texas, until he was 11 and then moved to Boca Raton, Florida, to support his older brother's tennis. Roddick became the world's No. 1 junior and won the US Open boys' title in 2000.
His weapon was the serve: first serves usually between 130 and 150 mph, a heavy kick second serve and a strong forehand behind it. In 2004, in a Davis Cup semifinal in Charleston, he served at 155 mph, a world record until Ivo Karlović passed it in 2011, and his 152 mph serve at the 2004 US Open is listed as the fastest at a major.
Coached by Tarik Benhabiles until 2003 and then by Brad Gilbert, he had his great season in 2003. He won the Masters events in Montreal and Cincinnati, then the US Open, beating Juan Carlos Ferrero 6–3, 7–6, 6–3 in the final. He reached No. 1 on 3 November 2003, held it for 13 weeks and finished the year at the top, also named ITF World Champion.
That US Open stayed his only major, largely because of Roger Federer. Roddick lost the Wimbledon finals of 2004, 2005 and 2009 to him, and the 2006 US Open final. The 2009 Wimbledon final ended 16–14 in the fifth set, the longest men's major final by games, and Roddick's 39 games won set a record for a major final. He also reached four Australian Open semifinals and finished nine years in a row in the top 10 from 2002.
He won 32 singles titles, five of them at Masters level. In the Davis Cup he played from 2001 to 2009 and again in 2011, with a 33–12 record and helped the United States win the 2007 title.
Roddick announced his retirement on his 30th birthday and played his last match at the 2012 US Open, losing to Juan Martín del Potro. Since then he has focused on his foundation and broadcasting, and since 2024 he has hosted the podcast "Served with Andy Roddick". He was inducted into the International Tennis Hall of Fame in 2017.